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As demonstrated in Figure 3, PCPA significantly decreased plasma 5-HT levels in wild type mice, which was accompanied by elevations in AST, ALT levels and liver necrosis and the reduction of 5-day's survival

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Permanently increased IIS with consecutive down-regulation of nuclear FoxO levels may thus promote the development of cancer [14]

Induction of macrophage insulin-like growth factor-I expression by the Th2 cytokines IL-4 and IL-13